4'-Chloropropiophenone CAS 6285-05-8
Factory Supply 4'-Chloropropiophenone CAS 6285-05-8 with Best Price
- Appearance: White powder
- Assay: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: 4′-Chloropropiophenone Supplement
4'-Chloropropiophenone: The Complete Guide
4'-Chloropropiophenone for Sale
Basic Info of 4'-Chloropropiophenone
1-(4-chlorophenyl)-1-propanon;4’-chloro-propiophenon;chloropropiophenone;Ethyl p-chlorophenyl ketone; 4′-Chloropropiophenone CAS 6285-05-8
Food additives; Pharmaceutical raw materials; Organic raw materials; Organic intermediate; Synthneses Material intermediate
What is 4'-Chloropropiophenone?
4′-Chloropropiophenone is a fragrant crooked ketone substance, a white crystalline solid with a melting point of 34-37 ° C. 4-Chloropropiophenone is a crucial intermediate with architectural composition.
4′-Chloropropiophenone is mainly utilized as a pharmaceutical intermediate for the synthesis of a new weight management medication, rimonabant (N-(piperidine)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl) )-4-methyl-IH-pyrazole-3-carboxamide) vital intermediates α-bromo 4-chloropropiophenone and also 4-(4-chlorophenyl)-3-methyl-2,4-di Ethyl oxobutyrate.
- 4′-Chloropropiophenone can used as a great chemical basic material for the synthesis of fine chemical products having p-chlorobenzene ring framework in the molecule, as well as can additionally be utilized as various other pharmaceutical as well as pesticide intermediates.
- 4′-Chloropropiophenone is a helpful synthetic intermediate. It can be utilized to prepare 4′-chloropropiophenone. It can additionally be used to manufacture bupropion (b689625) analogues.
- Rimonabant is a new weight loss drug, and α-bromo-4-chloropropiophenone is a key intermediate in the synthesis of rimonabant.
The Manager has Something to Say
This is William, CEO of Zhishang Chemical Co., Ltd.
Welcome to visit our factory . As the top chemical manufacturer, we have been striving for product quality, innovation , R&D, and customer service for the past 7 years. In the next 10 years or even longer, we are committed to becoming the most reliable chemical supplier in the world , creating a well-known international brand trusted by customers, with the spirit of “one meter wide, ten thousand meters deep”, we continue to focus on product research and development, continue to focus on customer service, continue to improve the supply chain service system, to create a professional chemical supply service team, to achieve win-win long-term cooperation. Please feel free to contact us if you have any questions.
- Email: firstname.lastname@example.org
- Phone: +86 176 5311 3209
- WhatsApp: +86 176 5311 3209
- WeChat: Zhishang17653113209
- Skype: +86 176 5311 3209
If you want to buy 4'-chloropropiophenone, pls contact us to get a free quote.
Application of 4'-Chloropropiophenone
CN201110155228.4 discloses a method for preparing a pharmaceutical intermediate α-bromo 4-chloropropiophenone, which takes 4-chloropropiophenone and liquid bromine as raw materials, and reacts in the presence of a catalyst to prepare α-bromo 4-propiophenone – Chloropropiophenone.
The method for synthesizing α-bromo-4-chloropropiophenone has the advantages of simple separation and purification process, short reaction time, high product purity, more than 97% product yield, low energy consumption, low environmental pollution and low cost, and realizes industrialized production. ideal process.
- CN201610864147 discloses hexythiazox and a preparation method thereof, and hexythiazox is an insecticide (acaricide).
Take 4-chloropropiophenone as the starting material, react with n-butyl nitrite in a mass ratio of 70:47 to generate ketoxime, and then carry out hydrogenation reduction to 2-amino-1-p-chlorophenylpropanol hydrochloride , 2-amino-1-p-chlorophenylpropanol hydrochloride directly reacts with carbon disulfide to synthesize trans-5-(4-chlorophenyl)-4-methyl-2-thiothiazolidinone, and then reacts with hydrogen peroxide Oxidation generates 5-(4-chlorophenyl)-4-methyl-2-oxothiazolidinone, 5-(4-chlorophenyl)-4-methyl-2-oxothiazolidinone is the same again Cyclohexyl cyanate undergoes addition reaction to obtain the final product hexythiazox.
The preparation method adopted in the present invention is suitable for industrial production, simplifies the technological process, improves the reaction yield, reduces the synthesis difficulty, reduces the formation of by-products, reduces the problem of environmental pollution in the preparation process, and reduces the production cost.
Preparation of 4'-Chloropropiophenone
In a four-necked reaction flask equipped with an electric stirrer, a reflux condenser and a thermometer, 15.65 g of p-chlorobenzoic acid, 51.8 g of propionic acid, and 2.5 g of catalyst were added successively. Condensation reaction is carried out by stirring for 12h, excess propionic acid is distilled out, and the temperature continues to rise until carbon dioxide gas starts to escape at 280 °C, and decarboxylation reaction is carried out under the temperature condition of 280 °C-285 °C, and 95% ethanol solution is used at the same time. Absorb the escaping carbon dioxide gas and the distilled liquid, after 2h of decarboxylation reaction, there is no liquid distillation in the four-port reactor, then stop the reaction, then cool and crystallize to obtain 4-chloropropiophenone product, 4-chloropropiophenone product. The yield reached 86.45%, and the melting point was 34-37°C.