4'-Chloropropiophenone CAS 6285-05-8

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  • Appearance: White powder
  • Assay: 99. 0%min
  • Stock: In stock
  • Sample: Available
  • Zhishang Chemical: 4′-Chloropropiophenone Supplement
6285-05-8

Basic Info of 4'-Chloropropiophenone

What is 4'-Chloropropiophenone?

4′-Chloropropiophenone is a fragrant crooked ketone substance, a white crystalline solid with a melting point of 34-37 ° C. 4-Chloropropiophenone is a crucial intermediate with architectural composition.

4′-Chloropropiophenone is mainly utilized as a pharmaceutical intermediate for the synthesis of a new weight management medication, rimonabant (N-(piperidine)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl) )-4-methyl-IH-pyrazole-3-carboxamide) vital intermediates α-bromo 4-chloropropiophenone and also 4-(4-chlorophenyl)-3-methyl-2,4-di Ethyl oxobutyrate.

4'-Chloropropiophenone Uses

  • 4′-Chloropropiophenone can used as a great chemical basic material for the synthesis of fine chemical products having p-chlorobenzene ring framework in the molecule, as well as can additionally be utilized as various other pharmaceutical as well as pesticide intermediates.
  • 4′-Chloropropiophenone is a helpful synthetic intermediate. It can be utilized to prepare 4′-chloropropiophenone. It can additionally be used to manufacture bupropion (b689625) analogues.
  • Rimonabant is a new weight loss drug, and α-bromo-4-chloropropiophenone is a key intermediate in the synthesis of rimonabant.

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Application of 4'-Chloropropiophenone

  • CN201110155228.4 discloses a method for preparing a pharmaceutical intermediate α-bromo 4-chloropropiophenone, which takes 4-chloropropiophenone and liquid bromine as raw materials, and reacts in the presence of a catalyst to prepare α-bromo 4-propiophenone – Chloropropiophenone.
    The method for synthesizing α-bromo-4-chloropropiophenone has the advantages of simple separation and purification process, short reaction time, high product purity, more than 97% product yield, low energy consumption, low environmental pollution and low cost, and realizes industrialized production. ideal process.

  • CN201610864147 discloses hexythiazox and a preparation method thereof, and hexythiazox is an insecticide (acaricide).
    Take 4-chloropropiophenone as the starting material, react with n-butyl nitrite in a mass ratio of 70:47 to generate ketoxime, and then carry out hydrogenation reduction to 2-amino-1-p-chlorophenylpropanol hydrochloride , 2-amino-1-p-chlorophenylpropanol hydrochloride directly reacts with carbon disulfide to synthesize trans-5-(4-chlorophenyl)-4-methyl-2-thiothiazolidinone, and then reacts with hydrogen peroxide Oxidation generates 5-(4-chlorophenyl)-4-methyl-2-oxothiazolidinone, 5-(4-chlorophenyl)-4-methyl-2-oxothiazolidinone is the same again Cyclohexyl cyanate undergoes addition reaction to obtain the final product hexythiazox.
    The preparation method adopted in the present invention is suitable for industrial production, simplifies the technological process, improves the reaction yield, reduces the synthesis difficulty, reduces the formation of by-products, reduces the problem of environmental pollution in the preparation process, and reduces the production cost.

Preparation of 4'-Chloropropiophenone

In a four-necked reaction flask equipped with an electric stirrer, a reflux condenser and a thermometer, 15.65 g of p-chlorobenzoic acid, 51.8 g of propionic acid, and 2.5 g of catalyst were added successively. Condensation reaction is carried out by stirring for 12h, excess propionic acid is distilled out, and the temperature continues to rise until carbon dioxide gas starts to escape at 280 °C, and decarboxylation reaction is carried out under the temperature condition of 280 °C-285 °C, and 95% ethanol solution is used at the same time. Absorb the escaping carbon dioxide gas and the distilled liquid, after 2h of decarboxylation reaction, there is no liquid distillation in the four-port reactor, then stop the reaction, then cool and crystallize to obtain 4-chloropropiophenone product, 4-chloropropiophenone product. The yield reached 86.45%, and the melting point was 34-37°C.

Reference

  1. 4′-Chloropropiophenone – PubChem
  2. [Chinese invention] CN201010153442.1 A preparation method of 4-chloropropiophenone

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