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3'-Chloropropiophenone CAS 34841-35-5

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  • Appearance: White powder
  • Assay: 99. 0%min
  • Stock: In stock
  • Sample: Available
  • Zhishang Chemical: 3′-Chloropropiophenone Supplement
34841-35-5

Basic Info of 3'-Chloropropiophenone

What is 3'-Chloropropiophenone?

3-Chloropropiophenone is a key intermediate in the synthesis of bupropion hydrochloride, dapoxetine and maraviroc. Bupropion hydrochloride is an antidepressant, which is a blocker of weak neuronal absorption of serotonin and norepinephrine. Bupropion can also be used as an adjunctive treatment for smoking cessation, viral infections, or sexual dysfunction.

Bupropion is a new type of antidepressant, and it can also play a smoking cessation effect by blocking the uptake of dopamine, serotonin and norepinephrine by nerves. It is widely used in clinical practice. The key intermediate of ketone. At present, the traditional process of industrial production of m-chloropropiophenone at home and abroad is that 1,2-dichloroethane is used as a solvent, aluminum trichloride is used as a catalyst, and Propiophenone is reacted with chlorine to obtain m-chloropropiophenone, but 1,2-dichloroethyl Alkane is flammable, highly toxic, and highly carcinogenic; aluminum trichloride vapor is irritating to the respiratory tract and causes bronchitis, and has a strong irritating effect on the skin and mucous membranes, and a large amount of acidic wastewater is produced during production. Industrial production is very difficult. Therefore, to seek advanced technology and low production cost, it is imperative to develop the green production technology of m-chloropropiophenone.

Reported in the patent, in 1,2-dichloroethane as solvent, under the catalysis of anhydrous aluminum trichloride, Propiophenone and chlorine generate chlorination reaction to synthesize m-chloropropiophenone, and the yield is 89%. Because this method uses a large amount of 1,2-dichloroethane as the reaction solvent during the synthesis, long-term contact and use will cause great harm to the human body. The pharmaceutical factory has banned the use of m-chloropropiophenone containing dichloroethane residues. As a raw material for the production of antidepressant bupropion.

3'-Chloropropiophenone Uses

  • 3′-Chloropropiophenone is a key intermediate in the synthesis of bupropion hydrochloride, dapoxetine and maraviroc. Mainly used in laboratory organic synthesis and chemical production process.
  • 3′-Chloropropiophenone is a reagent used for vinyl, alkylation and dienylation of ketones. It is also used to prepare thiazine derivatives with antibacterial activity.
  • 3′- Chlorophenyl acetone has been used to prepare 1- (3-chlorophenyl) – 1-phenyl-1-propanol.
  • 3′- Chlorophenyl acetone can be used as reactant (s) – 3-chloro-1-phenylpropanol was synthesized by biocatalytic asymmetric reduction.
    1- (3-chlorophenyl) – 1-phenyl-1-propanol is phenylated with diphenylzinc in the presence of dihydroxy bis (sulfonamide) ligand.
    (S) – dapoxetine, a selective serotonin reuptake inhibitor.

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Application of 3'-Chloropropiophenone

Preparation of 3'-Chloropropiophenone

Reference

  1. 3′-Chloropropiophenone – PubChem
  2. CN200410065482.5. A kind of method for preparing 3′-chloropropiophenone

Quality Control of 3'-Chloropropiophenone

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