2-Hydroxypropyl-Beta-Cyclodextrin CAS 128446-35-5 HPCD

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  • Appearance: White powder
  • Assay: 99. 0%min
  • Stock: In stock
  • Sample: Available
  • Zhishang Chemical: 2-Hydroxypropyl-Beta-Cyclodextrin Supplement
128446-35-5

Basic Info of 2-Hydroxypropyl-Beta-Cyclodextrin

What is 2-Hydroxypropyl-Beta-Cyclodextrin?

2-Hydroxypropyl-beta-cyclodextrin is among one of the most examined and also commonly used cyclodextrin derivatives. It is mainly used in food, medication and also cosmetics markets.

(2-Hydroxypropyl)- β- Cyclodextrin is a sort of hydroxyalkyl derivative, which can be utilized as preparation carrier to enhance the solubility of drugs in aqueous service, thus efficiently delivering medications to organic systems. It is generally made use of as α-、 β- and γ- Alternatives to cyclodextrins.

Hydroxypropyl betadex was prepared by treating the standard remedy of b-cyclodextrin with propylene oxide. The alternate mode can be affected by changing the pH worth. Low and high antacid focus are favorable for the formation of O-6 and O-2 replacement products, specifically. The resulting item mixture can be fine-tuned by preparative chromatography.

2-Hydroxypropyl-Beta-Cyclodextrin Uses

  • Hydroxypropyl-β-cyclodextrin (HBC) is a commonly made use of modified cyclodextrin with 7 sugar units developing a lipophilic cavity. After the drug is complexed with hydroxypropyl-β-cyclodextrin, the water solubility will certainly be substantially boosted. The number of 2-hydroxypropyl groups is between 5 and also 14.
  • 2-Hydroxypropyl-Beta-cyclodextrin can be utilized as a selective estrogen receptor modulator to prevent osteoporosis.
  • Enteric coating, sustained release preparation, oral and transdermal administration.
  • It is reported that hydroxypropyl betadex inclusion complexes show different mechanical properties from pure materials. It is reported that hydroxypropyl β- Glucodextrin is superior to unsubstituted β- The advantage of cyclodextrin is its greater water solubility.
  • Hydroxypropyl betadex has been extensively examined in medications and is mostly used as solubilizer of hydrophobic particles in dental liquids, oral solids, parenteral, pressurized metered dose inhalers, dry powder inhalers and local preparations. It has also been shown to act as a stabilizer during the processing and storage of formulations.

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Application of 2-Hydroxypropyl-Beta-Cyclodextrin

2-Hydroxypropyl-beta-cyclodextrin is an ideal injection solubilizer and pharmaceutical excipient, which can improve the water solubility of poorly soluble drugs, increase drug stability, improve drug bioavailability, and increase the efficacy of drugs or take The dosage is reduced, the release rate of the drug can be adjusted or controlled, and the toxic and side effects of the drug can be reduced.

  1. In the field of food as well as spice, it can enhance the security and also long-lasting result of nutritional particles, mask or remedy the bad scent as well as preference of food nutritional molecules, and boost the manufacturing process as well as product quality. The item has good solubility in water, as well as can be miscible with water in any type of proportion with a replacement level of 4 and also above, as well as can also be dissolved in 50% ethanol and also methanol.
  2. Made use of as stabilizer, emulsifier, deodorant, and so on in aesthetic raw materials, it can lower the irritability of organic particles in cosmetics to skin and also mucous membrane cells, boost the security of active components, as well as prevent the Volatilization as well as oxidation of nutrients. It has a specific family member hygroscopicity.
  3. In the pharmaceutical sector, it is a perfect injection solubilizer as well as pharmaceutical excipient as a result of its fairly reduced surface activity and also hemolytic activity and also no irritation to muscle mass.

Quality Control of 2-Hydroxypropyl-Beta-Cyclodextrin

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