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2-Acetylbutyrolactone CAS 517-23-7

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  • Appearance: Colorless liquid
  • Assay: 99. 0%min
  • Stock: In stock
  • Sample: Available
  • Zhishang Chemical: 2-Acetylbutyrolactone Supplement
517-23-7

Basic Info of 2-Acetylbutyrolactone

What is 2-Acetylbutyrolactone?

Alpa-acetyl-gama-butyl ester, likewise called 2-acetyl-γ-butyrolactone, is a crucial natural chemical raw material, an intermediate for the preparation of chlorophyll, as well as can likewise be utilized in the pharmaceutical market to make anti-angina pectoris medications. The raw materials for the preparation of vitamin B1 can additionally be used to synthesize 3,4-disubstituted pyridine as well as 5-(β-hydroxyethyl)-4-methylthiazole, which are widely utilized.

2-Acetylbutyrolactone is an important intermediate in the synthesis of chemical and pharmaceutical products such as vitamin B, 3,4-substituted pyridine, 5- (2-hydroxyethyl) – 4-methylthiazole. In the presence of 2-Acetylbutyrolactone, tert butyl isocyanate reacts with dialkyl acetylene dicarboxylate to form dialkyl (E) -2-{(tert butyl amino) [2-oxo-4,5-dihydro-3 (2H) – furanyl] methyl}-2-maleate. In addition, 2-Acetylbutyrolactone reacted with thiosemicarbazone and 3- (2-bromo-acetyl) – chrome-2-one in absolute ethanol to produce 3-{2-[5-hydroxyl-4- (2-hydroxy-ethyl) – 3-methyl-pyrazol-1-yl]-thiazol-4-yl}-chrome-2-one in good yield. In addition, 2-Acetylbutyrolactone can also be used as the raw material for the synthesis of pilocarpine, which is the main drug for the treatment of narrow-angle and wide-angle glaucoma. In addition, the chemical can also be used as a fluorescent reagent for the quantitative spectrofluorimetric determination of primary amines, which has been proved to be as accurate and accurate as the official or other reported methods.

2-Acetylbutyrolactone Uses

  • 2-Acetylbutyrolactone is an intermediate for the synthesis of 2,4-disubstituted pyridine. A fluorescent reagent for spectrofluorimetric determination of primary amine.
  • 2-Acetylbutyrolactone was used to synthesize 3,4-disubstituted pyridine; 5- (b-hydroxyethyl) – 4-methylthiazole.
  • 2-Acetylbutyrolactone is an important intermediate in the synthesis of vitamin B. It is also an intermediate for the synthesis of 3,4-disubstituted pyridine and 5-(β-hydroxyethyl)-4-methylthiazole.
  • Fluorescence spectrometry
    2-Acetylbutyrolactone itself has only slight fluorescence, but its derivatives show high UV fluorescence. Carbonyl group can easily react with amine to form Schiff base. It is for this reason that 2-Acetylbutyrolactone is often used to confirm the production of amines in organic synthesis. 2-Acetylbutyrolactone can also form fluorescent molecules with aromatic amines through the Japp Klingemann reaction.
  • Drug precursor
    2-Acetylbutyrolactone is used as a precursor of many drugs, including santalene and α- Methylene- γ- Butyrolactone.

Preparation of 2-Acetylbutyrolactone

2-Acetylbutyrolactone can be prepared by the condensation reaction of acetate (such as ethyl acetate) and butyrolactone in alkaline solution.

2-Acetylbutyrolactone can also be prepared by reacting ethylene oxide with ethyl acetoacetate under alkaline conditions.

Reference

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