1-Acetyl-4-(4-hydroxyphenyl)piperazine CAS 67914-60-7
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- Appearance: White powder
- Assay: 99. 0%min
- Stock: In stock
- Sample: Available
1-Acetyl-4-(4-hydroxyphenyl)piperazine: The Complete Guide
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Basic Info of 1-Acetyl-4-(4-hydroxyphenyl)piperazine
Side chain (ketoconazole);Ketoconazole side chain; 1-Acetyl 1-Acetyl-4-(hydroxyphenyl)piperazine; ketoconazole impurity 13; ketoconazole impurity; 4-(1-Acetylpiperazin-4-yl)phenol
Pharmaceutical raw materials; Inorganic salts
What is 1-Acetyl-4-(4-hydroxyphenyl)piperazine?
1-acetyl-4 – (4-hydroxyphenyl) piperazine (ahpp) is a piperazine derivative and a structural analogue of acetaminophen. The multi-step preparation of bis – (2-chloroethyl) amine hydrochloride and p-aminophenol has been reported.
Piperazine hexahydrate can be condensed with p-nitrochlorobenzene to produce 1 – (4-nitrophenyl) piperazine, and then react with acetic anhydride to obtain 1-acetyl-4 – (4-nitrophenyl) piperazine, which is prepared after nitro reduction, diazotization and hydrolysis.
- Intermediate of ketoconazole.
- It is used for the synthesis of ketoconazole and itraconazole.
- 1-acetyl-4 – (4-hydroxyphenyl) piperazine can be used to prepare 1-acetyl-4 – (4-octadecanoxyphenyl) piperazine.
- It can also be used in the multi-step synthesis of ketoconazole, its 1,2,4-triazole and thiazole analogues.
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