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α-Naphthoflavone CAS 604-59-1

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  • Appearance: Yellow powder
  • Purity: 99. 0%min
  • Stock: In stock
  • Sample: Available
  • Zhishang Chemical: α-Naphthoflavone Supplier & Manufacturer

Basic Info

What is α-Naphthoflavone?

α- Naphthalene flavone, additionally referred to as 7,8-benzoflavone and 2-phenyl-benzo (h) chrome-4-one, is an artificial flavone derivative, which is an efficient and affordable aromatase prevention with IC50 and Ki worths of 0.5 as well as 0.2 specifically μ M 。

α- Naphthoquinone is a reliable prevention of aromatase, which transforms testosterone right into estrogen. α – Naphthoflavone has been shown to cause irregular testicular development in young chickens.

α-Naphthoflavone Uses

α- Naphthylflavone is used as an indicator of oxidation and reduction.

α- Naphthylflavone is a kind of flavonoids that can act on μ- Opioid receptors to treat pain. It is also used as a non steroidal aromatase inhibitor for the treatment of breast cancer.

The extended flavonoids are produced by the formal fusion of benzene ring and the h side of flavonoids. A synthetic compound that is an inhibitor of aromatase (EC 1.14.14.14).

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Application of α-Naphthoflavone

Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription variable that can advertise the expression of stage I and also phase II allogenic chemical metabolic enzyme genes, including cytochrome P450 (CYP) subtypes CYP1A1 and also CYP1A2. α- Naphthalene flavone is a sort of flavone, which can regulate the metabolism of xenobiotics at numerous points. It annoys AhR and also obstructs the expression of phase I as well as stage II genes at nanomolar focus, although it can obstruct the expression of stage I as well as stage II genes at higher focus (10 μ M) Next fired up AhR. α- Naphthoflavone prevents CYP19 (aromatase), CYP1A1, CYP1A2 as well as CYP1B1 (IC50 is 500, 60, 6 and also 5 nM specifically), while it triggers CYP3A4 (Kd=7.4 μ M ) 。 In the existence of artificial estrogen α- Naphthene flavonoids might cause cancer causing impacts.

Reference

  1. alpha-Naphthoflavone – WikiPedia
  2. Kellis JT Jr; Vickery LE (1984). “Inhibition of human estrogen synthetase (aromatase) by flavones”. Science.

α-Naphthoflavone Supplier and Manufacturer

As a α-naphthoflavone supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best α-naphthoflavone raw materials to customers all over the world.

Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.

If you have a demand for α-naphthoflavone and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.

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